Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11646890 | 0.88 | RAB9A (0.43) | PRCPRAB9AGAAATMRET | |
| SCHEMBL23876659 | 0.88 | PRCP (0.44) | PRCPRAB9AGAASRD5A1SIGMAR1 | |
| SCHEMBL9940797 | 0.75 | KMT2A (0.42) | PRCPSIGMAR1 | |
| SCHEMBL9940591 | 0.75 | KMT2A (0.42) | PRCPSIGMAR1 | |
| SCHEMBL21149846 | 0.75 | KMT2A (0.42) | PRCPSIGMAR1 | |
| SCHEMBL1724425 | 0.75 | PRCP (0.70) | PRCPGAASIGMAR1IDO1PDPK1 | |
| SCHEMBL30371814 | 0.75 | KMT2A (0.42) | PRCPSIGMAR1 | |
| SCHEMBL22201161 | 0.75 | KMT2A (0.42) | PRCPSIGMAR1 | |
| SCHEMBL7797739 | 0.75 | SRD5A1 (0.64) | RAB9ASRD5A1SIGMAR1IDO1PDPK1 | |
| SCHEMBL14007698 | 0.75 | PRCP (0.44) | PRCPGAASIGMAR1IDO1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591583-B1 | Benzo (f) quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0532190-B1 | Benzo(f)quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0591582-B1 | Hexahydrobenzo (f) quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0531026-B1 | Hexahydrobenzo[f]quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 1998-11-18 | — | — | EP | disclosed |
| US-5710163-A | STEROID 5A-REDUCTASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-01-20 | — | — | US | disclosed |
| US-5670512-A | SKIN DISORDERS; REDUCTASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-09-23 | — | — | US | disclosed |
| US-5541190-A | TREATING BENIGN PROSTATIC HYPERPLASIA, MALE PATTERN BALDNESS, PROSTATIC CANCER, ANDROGENIC ALOPECIA | ELI LILLY AND COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| US-5495021-A | STEROID 5 ALPHA-REDUCTASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-27 | — | — | US | disclosed |
| US-5334767-A | Steroid 5a-reductase inhibitor | ELI LILLY AND COMPANY (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0591583-A1 | Benzo (f) quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0591582-A1 | Hexahydrobenzo (f) quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1994-04-13 | — | — | EP | disclosed |
| US-5250539-A | 5-alpha reductase inhibitors; administer as therapy for benign prostatic hyperplasia, hirsutism and acne | ELI LILLY AND COMPANY (US) | 1993-10-05 | — | — | US | disclosed |
| US-5239075-A | PROCESS FOR THE PREPARATION OF BENZO (F) QUINOLINONES | ELI LILLY AND COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0532190-A2 | Benzo f quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0531026-A1 | Hexahydrobenzo[f]quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |