Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7797922 | 0.93 | KDM4E (0.46) | MAP3K5KDM4EALDH1A1KMT2AMAPK1 | |
| SCHEMBL8184238 | 0.90 | MAP3K5 (0.44) | MAP3K5KDM4EALDH1A1KMT2AMAPK1 | |
| SCHEMBL8186096 | 0.89 | ROCK2 (0.46) | MAP3K5KDM4EALDH1A1KMT2AMAPK1 | |
| SCHEMBL8176110 | 0.89 | MAP3K5 (0.43) | MAP3K5KDM4EKMT2AMAPK1MEN1 | |
| SCHEMBL7791913 | 0.88 | MAP3K5 (0.43) | MAP3K5KDM4EALDH1A1KMT2AMAPK1 | |
| SCHEMBL7798063 | 0.88 | KMT2A (0.43) | MAP3K5KDM4EALDH1A1KMT2AMAPK1 | |
| SCHEMBL7797950 | 0.87 | KDM4E (0.44) | MAP3K5KDM4EALDH1A1KMT2AMAPK1 | |
| SCHEMBL7799945 | 0.87 | KMT2A (0.46) | MAP3K5KDM4EALDH1A1KMT2AMAPK1 | |
| SCHEMBL8191509 | 0.87 | MAP3K5 (0.42) | MAP3K5KMT2AMAPK1MEN1SMN1; SMN2 | |
| SCHEMBL7109075 | 0.86 | MAPT (0.50) | MAP3K5KDM4EALDH1A1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010025045-A1 | Substituted isoquinoline derivatives and their use as anticonvulsants | SMITHKLINE BEECHAM P.L.C. | 2001-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010025045-A1 | Substituted isoquinoline derivatives and their use as anticonvulsants | INA, GRIN2C, GRIN2A | MAP3K5 2929/4885KDM4E 910/4885ALDH1A1 494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.