Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7800211 | 1.00 | LTA4H (0.48) | LTA4HITGB3ITGA2BMAPTSMN1; SMN2 | |
| Ornithine Aketoglutarate SCHEMBL7792721 | 0.97 | LTA4H (0.48) | LTA4HITGB3ITGA2BMAPTSMN1; SMN2 | |
| Lysine SCHEMBL7792810 | 0.97 | LTA4H (0.48) | LTA4HITGB3ITGA2BMAPTSMN1; SMN2 | |
| Ornithine SCHEMBL7792718 | 0.97 | LTA4H (0.48) | LTA4HITGB3ITGA2BMAPTSMN1; SMN2 | |
| Lysine SCHEMBL7792811 | 0.97 | LTA4H (0.48) | LTA4HITGB3ITGA2BMAPTSMN1; SMN2 | |
| Lysine SCHEMBL7798394 | 0.95 | LTA4H (0.44) | LTA4HITGB3ITGA2BMAPTSMN1; SMN2 | |
| Lysine SCHEMBL7798391 | 0.95 | LTA4H (0.44) | LTA4HITGB3ITGA2BMAPTSMN1; SMN2 | |
| Lysine SCHEMBL7801015 | 0.95 | LTA4H (0.44) | LTA4HITGB3ITGA2BMAPTSMN1; SMN2 | |
| Ornithine SCHEMBL7800241 | 0.94 | LTA4H (0.49) | LTA4HITGB3ITGA2BMAPTSMN1; SMN2 | |
| Ornithine Aketoglutarate SCHEMBL7800245 | 0.94 | LTA4H (0.49) | LTA4HITGB3ITGA2BMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |