Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560540 | 0.92 | NPC1 (0.59) | NPC1MAPTTSHRLMNAKMT2A | |
| SCHEMBL7803121 | 0.90 | MAPT (0.43) | MAPTKMT2AMEN1HTTNPSR1 | |
| SCHEMBL7803067 | 0.89 | MAPT (0.51) | MAPTTSHRKMT2AMEN1HTT | |
| SCHEMBL7804711 | 0.83 | MAPT (0.43) | MAPTTSHRLMNAKMT2ANPSR1 | |
| SCHEMBL7803529 | 0.83 | CCKAR (0.43) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL6562222 | 0.81 | MAPT (0.47) | MAPTLMNAKMT2AMEN1HTT | |
| SCHEMBL6562673 | 0.80 | MAPT (0.58) | MAPTTSHRKMT2AMEN1HTT | |
| SCHEMBL6561366 | 0.80 | KDM4E (0.54) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL7804699 | 0.79 | MAPT (0.49) | NPC1MAPTTSHRLMNAKMT2A | |
| SCHEMBL7800642 | 0.79 | PDGFRB (0.39) | MAPTTSHRLMNAKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1075469-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Samjin Pharmaceutical Co., Ltd. (KR) | 2001-02-14 | — | — | EP | disclosed |
| WO-2000052001-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2000-09-08 | — | — | WO | disclosed |