Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 7/20 | 0.83 |
| ▸ | PAX8 | Q06710 | 5/20 | 0.83 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.83 |
| ▸ | MEN1 | O00255 | 9/20 | 0.77 |
| ▸ | THRB | P10828 | 9/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.77 |
| ▸ | BLM | P54132 | 8/20 | 0.77 |
| ▸ | RECQL | P46063 | 7/20 | 0.77 |
| ▸ | BRCA1 | P38398 | 6/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.77 |
| ▸ | USP2 | O75604 | 4/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.77 |
| ▸ | TOP2A | P11388 | 4/20 | 0.77 |
| ▸ | HTT | P42858 | 4/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.77 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805227 | 0.95 | S100A4 (0.83) | S100A4PAX8HSP90AA1MEN1THRB | |
| SCHEMBL7801104 | 0.93 | S100A4 (0.85) | S100A4PAX8HSP90AA1MEN1THRB | |
| SCHEMBL7795304 | 0.93 | S100A4 (0.81) | S100A4PAX8HSP90AA1MEN1THRB | |
| Hydrochloric Acid SCHEMBL11222593 | 0.92 | S100A4 (0.80) | S100A4PAX8HSP90AA1MEN1THRB | |
| SCHEMBL25015224 | 0.91 | S100A4 (0.82) | S100A4PAX8HSP90AA1MEN1THRB | |
| SCHEMBL162675 | 0.91 | S100A4 (0.82) | S100A4PAX8HSP90AA1MEN1THRB | |
| SCHEMBL30260668 | 0.91 | S100A4 (0.82) | S100A4PAX8HSP90AA1MEN1THRB | |
| SCHEMBL27337885 | 0.91 | S100A4 (0.82) | S100A4PAX8HSP90AA1MEN1THRB | |
| SCHEMBL8639928 | 0.91 | S100A4 (1.00) | S100A4PAX8HSP90AA1MEN1THRB | |
| SCHEMBL29338082 | 0.91 | S100A4 (1.00) | S100A4PAX8HSP90AA1MEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3153552-B2 | — | — | 2001-04-09 | — | — | JP | claimed |
| US-5496808-A | ANTITUMOR AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-03-05 | — | — | US | claimed |
| EP-0521458-B1 | Mono and bis alkylamino-anthracyclines | PHARMACIA SPA (IT) | 1996-02-21 | — | — | EP | claimed |
| WO-1993001201-A1 | MONO AND BIS ALKYLAMINO-ANTHRACYCLINES | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-01-21 | — | — | WO | claimed |
| EP-0521458-A1 | Mono and bis alkylamino-anthracyclines | PHARMACIA S.p.A. (IT) | 1993-01-07 | — | — | EP | claimed |
| US-5496808-A | ANTITUMOR AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-03-05 | — | — | US | disclosed |
| EP-0521458-B1 | Mono and bis alkylamino-anthracyclines | PHARMACIA SPA (IT) | 1996-02-21 | — | — | EP | disclosed |
| WO-1993001201-A1 | MONO AND BIS ALKYLAMINO-ANTHRACYCLINES | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-01-21 | — | — | WO | disclosed |
| EP-0521458-A1 | Mono and bis alkylamino-anthracyclines | PHARMACIA S.p.A. (IT) | 1993-01-07 | — | — | EP | disclosed |