Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11402512 | 0.83 | TDP1 (0.52) | TDP1SLC6A4CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL9264658 | 0.80 | GBA1 (0.56) | SLC6A4MAOA | |
| SCHEMBL3155613 | 0.77 | TDP1 (0.63) | TDP1SLC6A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL11358196 | 0.76 | TDP1 (0.50) | TDP1SLC6A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL656814 | 0.76 | SLC6A4 (0.73) | SLC6A4CYP1A2CYP2D6CYP2C19LDHA | |
| Bromide SCHEMBL7254135 | 0.75 | TDP1 (0.61) | TDP1SLC6A4ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4778145 | 0.75 | TDP1 (0.66) | TDP1SLC6A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL4251977 | 0.74 | TDP1 (0.59) | TDP1ALDH1A1SMN1; SMN2MAOBITGB3 | |
| SCHEMBL27175248 | 0.72 | TAAR1 (0.62) | SLC6A4ALDH1A1 | |
| SCHEMBL27175245 | 0.72 | TAAR1 (0.62) | SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673927-B1 | piperidines as anticholinergic agents | EISAI CO LTD (JP) | 2001-09-19 | — | — | EP | disclosed |
| EP-1116716-A1 | Piperidine and piperazine compounds for use in the treatment of Alzheimer | Eisai Co., Ltd. (JP) | 2001-07-18 | — | — | EP | disclosed |
| EP-0742207-A1 | 2-(Indan-1-one-2-yl-alkyl)-1-phenylalkyl-piperidines and processes for their preparation | Eisai Co., Ltd. (JP) | 1996-11-13 | — | — | EP | disclosed |
| EP-0673927-A1 | 4-[2-indanyl-1-one]alkylpiperidines as anticholinergic agents | Eisai Co., Ltd. (JP) | 1995-09-27 | — | — | EP | disclosed |
| EP-0579263-A1 | 1,4-Substituted piperidines as acetylchozinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1994-01-19 | — | — | EP | disclosed |
| US-5100901-A | Treatment of Alzheimer*s disease | EISAI CO., LTD. (JP) | 1992-03-31 | — | — | US | disclosed |
| US-4895841-A | Cyclic amine compounds with activity against acetylcholinesterase | EISAI CO., LTD. (JP) | 1990-01-23 | — | — | US | disclosed |
| EP-0296560-A2 | 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1988-12-28 | — | — | EP | disclosed |