Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7801436 | 0.80 | TDP1 (0.52) | SLC6A4MAOA | |
| SCHEMBL7492665 | 0.80 | GBA1 (0.56) | GBA1SLC6A2SLC6A4TAAR1MAOA | |
| SCHEMBL7871223 | 0.80 | GBA1 (0.56) | GBA1SLC6A2SLC6A4MAOASLC6A3 | |
| SCHEMBL7492670 | 0.80 | GBA1 (0.56) | GBA1SLC6A2SLC6A4TAAR1MAOA | |
| SCHEMBL7871873 | 0.80 | GBA1 (0.56) | GBA1SLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL7868320 | 0.76 | GBA1 (0.51) | GBA1SLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL5687527 | 0.76 | GBA1 (0.51) | GBA1SLC6A2SLC6A4TAAR1MAOA | |
| SCHEMBL7868325 | 0.76 | GBA1 (0.51) | GBA1SLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL27478385 | 0.76 | DPP4 (0.51) | GBA1EPHX1ANPEPSLC6A2SLC6A4 | |
| SCHEMBL7070397 | 0.73 | GBA1 (0.55) | GBA1SLC6A4MAOASIGMAR1SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |