Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.71 |
| ▸ | PDE4A | P27815 | 5/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.71 |
| ▸ | MET | P08581 | 3/20 | 0.71 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7801960 | 0.93 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DMET | |
| SCHEMBL7798931 | 0.91 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DMET | |
| SCHEMBL7800598 | 0.91 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DMET | |
| SCHEMBL7802139 | 0.91 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DMET | |
| SCHEMBL7793051 | 0.91 | PDE4B (0.75) | PDE4BPDE4APDE4CPDE4DMET | |
| SCHEMBL7798988 | 0.91 | MET (0.68) | PDE4BPDE4APDE4CPDE4DMET | |
| SCHEMBL6660936 | 0.91 | PDE4B (0.75) | PDE4BPDE4APDE4CPDE4DMET | |
| SCHEMBL7800567 | 0.90 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DMET | |
| SCHEMBL7798776 | 0.90 | PDE4B (0.79) | PDE4BPDE4APDE4CPDE4DMET | |
| SCHEMBL7798690 | 0.89 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723962-B1 | Arylalkyl-thiadiazinones | MERCK PATENT GMBH (DE) | 2001-07-04 | — | — | EP | disclosed |
| US-6025354-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-15 | — | — | US | disclosed |
| US-5747489-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-05 | — | — | US | disclosed |
| EP-0723962-A1 | Arylalkyl-thiadiazinones | MERCK PATENT GmbH (DE) | 1996-07-31 | — | — | EP | disclosed |