Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.53 |
| ▸ | RET | P07949 | 12/20 | 0.50 |
| ▸ | KDR | P35968 | 9/20 | 0.50 |
| ▸ | KIF5B | P33176 | 8/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.49 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29801726 | 0.93 | EGFR (0.53) | EGFRRETKDRKIF5BRIPK2 | |
| SCHEMBL216888 | 0.93 | EGFR (0.53) | EGFRRETKDRKIF5BRIPK2 | |
| Hydrochloric Acid SCHEMBL28006468 | 0.91 | EGFR (0.52) | EGFRRETKDRKIF5BRIPK2 | |
| SCHEMBL2476964 | 0.89 | RET (0.55) | EGFRRETKDRKIF5BRIPK2 | |
| SCHEMBL11315816 | 0.84 | EGFR (0.52) | EGFRRETKDRKIF5BRIPK2 | |
| SCHEMBL20813470 | 0.84 | EGFR (0.52) | EGFRRETKDRKIF5BRIPK2 | |
| SCHEMBL10296332 | 0.84 | KDR (0.52) | EGFRRETKDRKIF5BRIPK2 | |
| SCHEMBL10940331 | 0.83 | EGFR (0.52) | EGFRRETKDRKIF5BRIPK2 | |
| SCHEMBL23500791 | 0.83 | RET (0.43) | EGFRRETKDRKIF5BRIPK2 | |
| SCHEMBL22323303 | 0.83 | TRPA1 (0.50) | EGFRRETKDRKIF5BRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635498-B1 | Quinazoline derivatives and their use as anti-cancer agents | SYNGENTA LTD (GB) | 2001-04-18 | — | — | EP | disclosed |
| US-5475001-A | Quinazoline derivatives | ZENECA LIMITED (GB) | 1995-12-12 | — | — | US | disclosed |
| WO-1995003283-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS | ZENECA LIMITED (GB) | 1995-02-02 | — | — | WO | disclosed |
| EP-0635498-A1 | Quinazoline derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | disclosed |