Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.55 |
| ▸ | PDE4A | P27815 | 15/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.55 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259135 | 1.00 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7798512 | 0.93 | GPR119 (0.49) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7798649 | 0.93 | GPR119 (0.49) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7800758 | 0.92 | GPR119 (0.48) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7798516 | 0.91 | GPR119 (0.48) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL144197 | 0.91 | GPR119 (0.48) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL142545 | 0.90 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL143229 | 0.90 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7800478 | 0.90 | GPR119 (0.47) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL9591714 | 0.90 | GPR119 (0.47) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723962-B1 | Arylalkyl-thiadiazinones | MERCK PATENT GMBH (DE) | 2001-07-04 | — | — | EP | disclosed |
| US-6025354-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-15 | — | — | US | disclosed |
| US-5883090-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-03-16 | — | — | US | disclosed |
| US-5747489-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-05 | — | — | US | disclosed |
| EP-0723962-A1 | Arylalkyl-thiadiazinones | MERCK PATENT GmbH (DE) | 1996-07-31 | — | — | EP | disclosed |
| US-5434149-A | Thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0618201-A1 | Thiadiazinones and their use in the treatment of cardiovascular or asthmatic conditions | MERCK PATENT GmbH (DE) | 1994-10-05 | — | — | EP | disclosed |