Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 6/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812269 | 0.89 | FFAR1 (0.48) | KDM4EMITFALDH1A1HTTCDK8 | |
| SCHEMBL7807544 | 0.88 | KDM4E (0.45) | KDM4EMITFALDH1A1HTTCDK8 | |
| SCHEMBL7815283 | 0.88 | KDM4E (0.45) | KDM4EMITFALDH1A1HTTCDK8 | |
| SCHEMBL7815281 | 0.84 | FFAR1 (0.44) | KDM4EMITFALDH1A1HTTCDK8 | |
| SCHEMBL7807790 | 0.83 | TACR1 (0.55) | ALDH1A1HTTCDK8CLK4HSP90AA1 | |
| SCHEMBL7809517 | 0.83 | TACR1 (0.47) | ALDH1A1TDP1 | |
| SCHEMBL6961996 | 0.82 | MEN1 (0.47) | TDP1 | |
| SCHEMBL7811343 | 0.81 | TACR1 (0.49) | HTTHSP90AA1TDP1 | |
| SCHEMBL7807768 | 0.80 | TACR1 (0.44) | ALDH1A1TDP1 | |
| SCHEMBL7803017 | 0.79 | KDM4E (0.43) | KDM4EMITFALDH1A1HTTCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773929-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2001-10-31 | — | — | EP | disclosed |
| US-5654316-A | Piperidine derivatives as neurokinin antagonists | SCHERING CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |