Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1485619 | 1.00 | HDAC4 (0.37) | HDAC4HDAC2HDAC8HDAC6ALOX15 | |
| SCHEMBL1485620 | 1.00 | HDAC4 (0.37) | HDAC4HDAC2HDAC8HDAC6ALOX15 | |
| SCHEMBL8474760 | 1.00 | HDAC4 (0.37) | HDAC4HDAC2HDAC8HDAC6ALOX15 | |
| SCHEMBL49260 | 0.97 | HDAC4 (0.38) | HDAC4HDAC2HDAC8HDAC6ALOX15 | |
| SCHEMBL49445 | 0.88 | HDAC4 (0.36) | HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL27831398 | 0.86 | HDAC3 (0.34) | HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL1485737 | 0.79 | HDAC4 (0.34) | HDAC4HDAC2HDAC8HDAC6ALOX15 | |
| SCHEMBL1485734 | 0.79 | HDAC4 (0.34) | HDAC4HDAC2HDAC8HDAC6ALOX15 | |
| SCHEMBL24060404 | 0.79 | — | — | |
| SCHEMBL9934647 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934268-A4 | PROCESS FOR PREPARING 2-AZADIHYDROXYBICYCLO 2.2.1]HEPTANE COMPOUNDS AND THE L-TARTARIC ACID SALT OF THE COMPOUND | RHONE POULENC RORER PHARMA (US) | 2001-04-18 | — | — | EP | disclosed |
| EP-0934268-A1 | PROCESS FOR PREPARING 2-AZADIHYDROXYBICYCLO 2.2.1]HEPTANE COMPOUNDS AND THE L-TARTARIC ACID SALT OF THE COMPOUND | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-08-11 | — | — | EP | disclosed |
| US-5886192-A | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds | RHONE-POULENC RORER S.A. (FR) | 1999-03-23 | — | — | US | disclosed |
| US-5831096-A | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1! heptane compounds | RHONE-POULENC RORER S.A. (FR) | 1998-11-03 | — | — | US | disclosed |
| US-5808093-A | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds | RHONE-POULENC RORER S.A. (FR) | 1998-09-15 | — | — | US | disclosed |
| WO-1998016510-A1 | PROCESS FOR PREPARING 2-AZADIHYDROXYBICYCLO[2.2.1]HEPTANE COMPOUNDS AND THE L-TARTARIC ACID SALT OF THE COMPOUND | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-04-23 | — | — | WO | disclosed |
| US-5684159-A | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds | RHONE-POULENC RORER S.A. (FR) | 1997-11-04 | — | — | US | disclosed |