Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estriol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 6/20 | 1.00 |
| ▸ | ESR2 known ✓ | Q92731 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | SHBG | P04278 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 2/20 | 1.00 |
| ▸ | SERPINA6 | P08185 | 2/20 | 1.00 |
| ▸ | AR | P10275 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | SNCA | P37840 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 1.00 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | STS | P08842 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estriol SCHEMBL12180048 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL14373308 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL4896486 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL7004654 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL223196 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL13123063 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL23743979 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Epiestriol SCHEMBL221084 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL223226 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL8941750 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 24521 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747621-A1 | SPECIFIC AND LABEL-FREE SENSING OF SMALL MOLECULE TARGETS USING BIOLOGICAL TRANSISTORS | B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University (IL) | 2026-05-27 | — | — | EP | claimed |
| EP-4739292-A1 | A THREE-LAYERED INTRAVAGINAL RING | Sever Pharma Solutions (SE) | 2026-05-13 | — | — | EP | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-20260115204-A1 | ENTHESIS HEALING | UNIV UTAH RES FOUND (US) | 2026-04-30 | — | — | US | claimed |
| EP-4732908-A2 | CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS | Biomed Valley Discoveries, Inc. (US) | 2026-04-29 | — | — | EP | claimed |
| EP-4719422-A1 | PROGESTOGEN-FREE ORAL DOSAGE UNIT FOR USE IN FEMALE CONTRACEPTION AND TREATMENT OF ENDOMETRIOSIS | Pandora Endocrine Innovation B.V. (NL) | 2026-04-08 | — | — | EP | claimed |
| US-20260086089-A1 | DEVICE, METHOD AND SYSTEM FOR DIAGNOSING, MONITORING AND PREDICTING CHRONIC HEALTH CONDITIONS THROUGH URINE BIOMARKERS | HERSTASIS HEALTH FOUND (CA) | 2026-03-26 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| CN-121586586-A | Process for preparing ophthalmic compositions of low solubility materials | 全福生物科技股份有限公司 | 2026-02-27 | — | — | CN | claimed |
| EP-4698662-A2 | REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES | AskBio Inc. (US) | 2026-02-25 | — | — | EP | claimed |
| US-4166103-A | ABSORBERS, RADIOIMMUNOASSAY | AMES-YISSUM LTD. (IL) | 1979-08-28 | — | — | US | claimed |
| EP-0003583-A1 | Compositions for cytochemical investigation, their use and method for the detection of steroid hormone receptors in human tissues | Lee, Sin Hang (US) | 1979-08-22 | — | — | EP | claimed |
| US-4145416-A | ESTRADIOL AND ESTRIOL DERIVATIVES | SCHERING, A.G. (DE) | 1979-03-20 | — | — | US | claimed |
| US-4115539-A | RADIOIMMUNOASSAY, REACTION PRODUCT WITH ISOCYANATES | UNION CARBIDE CORPORATION (US) | 1978-09-19 | — | — | US | claimed |
| US-4097586-A | Immunochemical assay method | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1978-06-27 | — | — | US | claimed |
| US-4076811-A | MENOPAUSE, ESTRADIOL ESTROGEN | SCHERING AKTIENGESELLSCHAFT (DT) | 1978-02-28 | — | — | US | claimed |
| US-4022878-A | NATIVE HOMOLOGOUS HAPTEN OR ANTIGEN | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1977-05-10 | — | — | US | claimed |
| US-4014987-A | VAGINAL DEVICE; USING A HYDROPHOBIC POLYCARBOXYLIC ACID AS DRUG RELEASE RATE CONTROLLER | ALZA CORPORATION (US) | 1977-03-29 | — | — | US | claimed |
| US-3975511-A | Solid phase radioimmunoassay | CORNING GLASS WORKS (US) | 1976-08-17 | — | — | US | claimed |
| US-3939186-A | Process for producing ethers of steroids | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JA) | 1976-02-17 | — | — | US | claimed |