Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | PDE2A | O00408 | 3/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | POLQ | O75417 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2600028 | 0.80 | IDO1 (0.54) | IDO1PDE2ADAOSLC6A4SLC6A2 | |
| SCHEMBL21654297 | 0.76 | IDO1 (0.50) | IDO1PDE2ADAOSLC6A4SLC6A2 | |
| SCHEMBL6789942 | 0.72 | IDO1 (0.58) | IDO1PDE2ADAOSLC6A4SLC6A2 | |
| SCHEMBL857195 | 0.72 | IDO1 (0.58) | IDO1PDE2ADAOSLC6A4SLC6A2 | |
| SCHEMBL29738028 | 0.72 | IDO1 (0.58) | IDO1PDE2ADAOSLC6A4SLC6A2 | |
| SCHEMBL11035192 | 0.72 | IDO1 (0.40) | IDO1PDE2ADAOCYP3A4GAA | |
| SCHEMBL20820505 | 0.71 | EPHX2 (0.42) | IDO1PDE2ACYP2D6GAAMEN1 | |
| SCHEMBL12775998 | 0.71 | IDO1 (0.38) | IDO1PDE2ADAOGAA | |
| SCHEMBL22728326 | 0.71 | IDO1 (0.45) | IDO1PDE2ADAOSLC6A4SLC6A2 | |
| SCHEMBL2600180 | 0.69 | IDO1 (0.54) | IDO1PDE2ADAOSLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-A1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | AstraZeneca AB (SE) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062506-A1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | disclosed |