Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | DGKZ | Q13574 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22728332 | 0.88 | IDO1 (0.45) | IDO1PDE2ASLC6A4ARCETP | |
| SCHEMBL22728334 | 0.83 | RIPK1 (0.41) | IDO1DAOSLC6A4SLC6A2HTR2A | |
| SCHEMBL21654297 | 0.78 | IDO1 (0.50) | IDO1PDE2ADAOSLC6A4SLC6A2 | |
| SCHEMBL22728339 | 0.76 | IDO1 (0.46) | IDO1SLC6A4SLC6A2SLC6A3PPARG | |
| SCHEMBL2600028 | 0.75 | IDO1 (0.54) | IDO1PDE2ADAOSLC6A4SLC6A2 | |
| SCHEMBL6789942 | 0.75 | IDO1 (0.58) | IDO1PDE2ADAOSLC6A4SLC6A2 | |
| SCHEMBL22728328 | 0.74 | HTR2A (0.47) | IDO1SLC6A4CTSSCTSKHTR2A | |
| SCHEMBL30970519 | 0.74 | IDO1 (0.53) | IDO1PDE2ADAOSLC6A4SLC6A2 | |
| SCHEMBL195125 | 0.74 | IDO1 (0.53) | IDO1PDE2ADAOSLC6A4SLC6A2 | |
| SCHEMBL22728367 | 0.72 | TAAR1 (0.33) | SLC6A4ARHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |