Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | PGK2 | P07205 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24914919 | 0.85 | CCR1 (0.35) | CCR1HCRTR1HCRTR2KCNH2 | |
| SCHEMBL20436470 | 0.83 | CCR1 (0.36) | CCR1HCRTR1HCRTR2KCNH2NPSR1 | |
| SCHEMBL20436477 | 0.83 | CCR1 (0.36) | CCR1HCRTR1HCRTR2KCNH2NPSR1 | |
| SCHEMBL30382126 | 0.82 | HCRTR1 (0.42) | CCR1HCRTR1HCRTR2 | |
| SCHEMBL536688 | 0.82 | HCRTR1 (0.42) | CCR1HCRTR1HCRTR2 | |
| SCHEMBL2440105 | 0.80 | CCR1 (0.40) | CCR1HCRTR1HCRTR2KCNH2NPSR1 | |
| SCHEMBL23355519 | 0.78 | HSD11B1 (0.36) | CCR1HSD11B1 | |
| SCHEMBL23355654 | 0.78 | PPARG (0.35) | CCR1HCRTR1HCRTR2KCNH2NPSR1 | |
| SCHEMBL24915287 | 0.77 | CCR1 (0.38) | CCR1HCRTR1HCRTR2NPSR1HSD11B1 | |
| SCHEMBL21790630 | 0.77 | ADORA2A (0.42) | CCR1HCRTR1HCRTR2HSD11B1PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788497-B1 | BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC (CA) | 2001-05-23 | — | — | EP | disclosed |
| US-5552437-A | ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY, AND CYTOPROTECTIVE AGENTS | MERCK FROSST CANADA, INC. (CA) | 1996-09-03 | — | — | US | disclosed |
| WO-1996013500-A1 | BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1996-05-09 | — | — | WO | disclosed |