Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.69 |
| ▸ | HTR1D | P28221 | 10/20 | 0.69 |
| ▸ | HTR1B | P28222 | 10/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812619 | 0.89 | HTR1A (0.73) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL6308697 | 0.86 | HTR1A (0.67) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7803798 | 0.85 | HTR1A (0.64) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7810713 | 0.84 | HTR1A (0.62) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL6312894 | 0.84 | HTR1A (0.75) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7816481 | 0.83 | HTR1A (0.67) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL8186008 | 0.83 | HTR1A (0.61) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL7812501 | 0.83 | HTR1A (0.66) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL8186003 | 0.83 | HTR1A (0.66) | HTR1AHTR1DHTR1BKCNH2SLC6A9 | |
| SCHEMBL27371183 | 0.82 | HTR1A (0.65) | HTR1AHTR1DHTR1BKCNH2SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| EP-0767782-B1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER (US) | 2001-10-31 | — | — | EP | disclosed |
| CN-1064350-C | Aryl and heteroaryl alkoxynaphtalene derivatives | PFIZER (US) | 2001-04-11 | — | — | CN | disclosed |
| US-6166020-A | Aryl and heteroaryl alkoxynaphthalene derivatives | PFIZER INC. (US) | 2000-12-26 | — | — | US | disclosed |
| EP-0795328-A1 | Use of naphthalene derivatives in treating lung carcinoma | PFIZER INC. (US) | 1997-09-17 | — | — | EP | disclosed |
| CN-1151729-A | Aryl and heteroaryl alkoxynaphtalene derivatives | PFIZER (US) | 1997-06-11 | — | — | CN | disclosed |
| EP-0767782-A1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER INC. (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000720-A1 | ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES | PFIZER INC. (US) | 1996-01-11 | — | — | WO | disclosed |