Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 17/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.53 |
| ▸ | TOP2A | P11388 | 1/20 | 0.52 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1986275 | 0.97 | GSK3B (0.60) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| Fluoride SCHEMBL7804066 | 0.95 | GSK3B (0.58) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL1343006 | 0.88 | GSK3B (0.65) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL500863 | 0.84 | GSK3B (0.64) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL7810902 | 0.83 | GSK3B (0.48) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL9689537 | 0.82 | GSK3B (0.68) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL7812725 | 0.82 | CACNA1F (0.57) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL7816829 | 0.82 | KCNH2 (0.57) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL7813328 | 0.81 | KCNH2 (0.56) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL1345769 | 0.81 | GSK3B (0.70) | GSK3BCACNA1FPOLBMAPK1CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610958-B1 | Intermediates in the preparation of 4-oxoquinoline-3-carboxylic acid derivatives | UBE INDUSTRIES (JP) | 2001-10-04 | — | — | EP | disclosed |
| US-5496951-A | 1-CYCLOPROPYL-6-FLUORO-8-FLUORINATED METHOXY COMPOUNDS INCLUDING BORON DIFLUORIDE CHELATE; CHEMICAL INTERMEDIATES AND ANTIBACTERIAL AGENTS | SANKYO COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5436367-A | 3, 4-difluorobenzoic acid derivatives | SANKO COMPANY, LIMITED (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0352123-B1 | 4-Oxoquinoline-3-carboxylic acid derivatives, their preparation and their use | UBE INDUSTRIES (JP) | 1995-01-18 | — | — | EP | disclosed |
| US-5348961-A | Antibacterial agents | SANKYO COMPANY LIMITED (JP) | 1994-09-20 | — | — | US | disclosed |
| EP-0610958-A2 | Intermediates in the preparation of 4-oxoquinoline-3-carboxylic acid derivatives | UBE INDUSTRIES, LTD. (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5073556-A | Bactericides | SANKYO COMPANY LIMITED (JP) | 1991-12-17 | — | — | US | disclosed |
| EP-0352123-A2 | 4-Oxoquinoline-3-carboxylic acid derivatives, their preparation and their use | UBE INDUSTRIES LIMITED (JP) | 1990-01-24 | — | — | EP | disclosed |