Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345019 | 0.92 | GSK3B (0.50) | GSK3BTOP2ATOP2BADRB2CACNA1F | |
| SCHEMBL1344898 | 0.87 | STAT3 (0.54) | GSK3BTOP2ATOP2BADRB2CACNA1F | |
| SCHEMBL1986275 | 0.86 | GSK3B (0.60) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL6880793 | 0.86 | GSK3B (0.50) | GSK3BTOP2ATOP2BADRB2CACNA1F | |
| SCHEMBL1344855 | 0.85 | GSK3B (0.52) | GSK3BTOP2ATOP2BADRB2CACNA1F | |
| SCHEMBL1982631 | 0.85 | ADRB2 (0.42) | GSK3BTOP2ATOP2BADRB2CACNA1F | |
| Fluoride SCHEMBL7804066 | 0.84 | GSK3B (0.58) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL9688633 | 0.84 | CACNA1F (0.49) | GSK3BTOP2ATOP2BADRB2CACNA1F | |
| SCHEMBL7804069 | 0.83 | GSK3B (0.57) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL5704363 | 0.82 | GSK3B (0.51) | GSK3BTOP2ATOP2BADRB2CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610958-B1 | Intermediates in the preparation of 4-oxoquinoline-3-carboxylic acid derivatives | UBE INDUSTRIES (JP) | 2001-10-04 | — | — | EP | disclosed |
| US-5496951-A | 1-CYCLOPROPYL-6-FLUORO-8-FLUORINATED METHOXY COMPOUNDS INCLUDING BORON DIFLUORIDE CHELATE; CHEMICAL INTERMEDIATES AND ANTIBACTERIAL AGENTS | SANKYO COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5436367-A | 3, 4-difluorobenzoic acid derivatives | SANKO COMPANY, LIMITED (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0352123-B1 | 4-Oxoquinoline-3-carboxylic acid derivatives, their preparation and their use | UBE INDUSTRIES (JP) | 1995-01-18 | — | — | EP | disclosed |
| US-5348961-A | Antibacterial agents | SANKYO COMPANY LIMITED (JP) | 1994-09-20 | — | — | US | disclosed |
| EP-0610958-A2 | Intermediates in the preparation of 4-oxoquinoline-3-carboxylic acid derivatives | UBE INDUSTRIES, LTD. (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5073556-A | Bactericides | SANKYO COMPANY LIMITED (JP) | 1991-12-17 | — | — | US | disclosed |
| EP-0352123-A2 | 4-Oxoquinoline-3-carboxylic acid derivatives, their preparation and their use | UBE INDUSTRIES LIMITED (JP) | 1990-01-24 | — | — | EP | disclosed |