SCHEMBL7804202

SCHEMBL7804202

CSc1c(C(C)=O)c(=O)[nH]c2c(CC(F)(F)F)cc(Cl)cc12

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GRIN1 Q05586 2/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33
MAPT P10636 1/20 0.33
CAPN1 P07384 2/20 0.32
CSF1R P07333 1/20 0.31
ALDH1A1 P00352 2/20 0.31
CTSD P07339 1/20 0.31
CTSL P07711 1/20 0.31
CTSB P07858 1/20 0.31
CTSH P09668 1/20 0.31
ALOX15 P16050 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7809688 0.82 CAPN1 (0.40) GRIN1GRIN2DGRIN3BGRIN2AGRIN2B
SCHEMBL7804199 0.81 CAPN1 (0.34) MAPTCAPN1CSF1RALDH1A1
SCHEMBL7809501 0.71 CAPN1 (0.34) CAPN1
SCHEMBL7813746 0.70 KDM4E (0.35) GRIN1GRIN2DGRIN3BGRIN2AGRIN2B
SCHEMBL7803957 0.69 CAPN1 (0.36) GRIN1GRIN2DGRIN3BGRIN2AGRIN2B
SCHEMBL7811068 0.69 KDM4E (0.35) CAPN1
SCHEMBL7810983 0.69 CAPN1 (0.44) MAPTCAPN1ALDH1A1CTSDCTSL
SCHEMBL7810952 0.68 RXFP1 (0.47)
SCHEMBL7809700 0.68 CAPN1 (0.39) MAPTCAPN1CSF1RALDH1A1
SCHEMBL7809564 0.68 CAPN1 (0.46) CAPN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0533882-B1 2-QUINOLINONE DERIVATIVES, METHODS FOR PREPARING THE SAME AND FUNGICIDES AND INSECTICIDES INCLUDING THEM KOREA RES INST CHEM TECH (KR) 2001-02-07 EP disclosed
US-5430153-A Insecticides, fungicides KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1995-07-04 US disclosed
WO-1992017452-A1 2-QUINOLINONE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1992-10-15 WO disclosed