Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 4/20 | 0.50 |
| ▸ | FNTB | P49356 | 4/20 | 0.50 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | DBH | P09172 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7748921 | 0.99 | FNTA (0.49) | FNTAFNTBPGGT1BCYP19A1CYP11B1 | |
| SCHEMBL8865500 | 0.87 | CYP19A1 (0.49) | CYP19A1ALDH1A1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7749564 | 0.85 | CYP11B1 (0.58) | FNTAFNTBPGGT1BCYP19A1CYP11B1 | |
| SCHEMBL8170527 | 0.85 | CYP11B1 (0.58) | FNTAFNTBPGGT1BCYP19A1CYP11B1 | |
| SCHEMBL2789150 | 0.82 | CYP11B1 (0.61) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8865733 | 0.81 | CYP11B1 (0.62) | CYP11B1CYP11B2PTGDR2 | |
| Hydrochloric Acid SCHEMBL8763109 | 0.80 | CYP11B1 (0.60) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL3821317 | 0.78 | CYP11B1 (0.73) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8248670 | 0.78 | ACE2 (0.70) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL1690916 | 0.78 | ACE2 (0.70) | FNTAFNTBPGGT1BCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891352-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-5869682-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0891352-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036891-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |
| EP-0783517-A2 | THIOL-FREE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| US-5627202-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-06 | — | — | US | disclosed |
| WO-1997001275-A1 | COMBINATIONS OF INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-01-16 | — | — | WO | disclosed |
| WO-1996010034-A2 | THIOL-FREE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| EP-0324377-A2 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-19 | — | — | EP | disclosed |