Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 1/20 | 0.69 |
| ▸ | CPB2 | Q96IY4 | 14/20 | 0.60 |
| ▸ | CPB1 | P15086 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7748924 | 0.99 | CPA1 (0.67) | CPA1CPB2CPB1MAPTCYP19A1 | |
| SCHEMBL7749570 | 0.85 | CPA1 (0.50) | CPA1CPB2CPB1MAPT | |
| SCHEMBL8865742 | 0.81 | CPA1 (0.76) | CPA1CPB2CPB1CYP19A1 | |
| SCHEMBL27605640 | 0.79 | MEN1 (0.44) | CPA1MAPT | |
| SCHEMBL7053727 | 0.78 | CPA1 (0.71) | CPA1CPB2CPB1CYP19A1 | |
| Hydrochloric Acid SCHEMBL8495732 | 0.77 | CPA1 (0.69) | CPA1CPB2CPB1CYP19A1 | |
| SCHEMBL6810226 | 0.74 | KMT2A (0.52) | CPA1MAPT | |
| SCHEMBL6810144 | 0.74 | KMT2A (0.52) | CPA1MAPT | |
| Hydrochloric Acid SCHEMBL8351982 | 0.73 | KMT2A (0.39) | CPA1CPB2 | |
| SCHEMBL8865506 | 0.73 | CYP19A1 (0.47) | CPA1CPB2CPB1MAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891352-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-5869682-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0891352-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036891-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |
| EP-0783517-A2 | THIOL-FREE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| US-5627202-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-06 | — | — | US | disclosed |
| WO-1997001275-A1 | COMBINATIONS OF INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-01-16 | — | — | WO | disclosed |
| WO-1996010034-A2 | THIOL-FREE INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |