SCHEMBL7804423

SCHEMBL7804423

NC1=NC(C2CCC2)Nc2cccc(F)c21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 15/20 1.00
NOS1 P29475 9/20 1.00
NOS3 P29474 9/20 1.00
HTR5A P47898 1/20 0.33
PBRM1 Q86U86 2/20 0.32
IDO1 P14902 1/20 0.31
TDO2 P48775 1/20 0.31
SMARCA2 P51531 1/20 0.31
SMARCA4 P51532 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8381996 0.99 NOS2 (0.97) NOS2NOS1NOS3HTR5APBRM1
SCHEMBL7806714 0.77 NOS2 (1.00) NOS2NOS1NOS3
Hydrochloric Acid SCHEMBL8377856 0.76 NOS2 (0.97) NOS2NOS1NOS3
SCHEMBL7803360 0.74 NOS2 (1.00) NOS2NOS1NOS3
Hydrochloric Acid SCHEMBL8381699 0.73 NOS2 (0.97) NOS2NOS1NOS3
SCHEMBL7803456 0.71 NOS2 (0.56) NOS2NOS1NOS3HTR5APBRM1
SCHEMBL7806675 0.71 NOS2 (0.81) NOS2NOS1NOS3PBRM1
SCHEMBL7805021 0.70 NOS2 (1.00) NOS2NOS1NOS3
Hydrochloric Acid SCHEMBL8379502 0.70 NOS2 (0.55) NOS2NOS1NOS3HTR5APBRM1
Hydrochloric Acid SCHEMBL8517333 0.70 NOS2 (0.79) NOS2NOS1NOS3PBRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248745-B1 MIXTURE COMPRISING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR AND A 1,2-DIHYDRO-4-AMINOQUINAZOLINE DERIVATIVE INHIBITOR OF INDUCED NITRIC OXIDE SYNTHASE (INOS); NON-STEROIDAL ANTIINFLAMMATORY AGENTS ASTRAZENECA AB (SE) 2001-06-19 US claimed
EP-1100505-A1 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR AstraZeneca AB (SE) 2001-05-23 EP claimed
WO-2000000200-A1 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR ASTRAZENECA AB (SE) 2000-01-06 WO claimed
CN-1204327-A Pharmaceutically active quinazoline compounds ASTRA PHARMA PROD (GB) 1999-01-06 CN disclosed
EP-0858451-A1 PHARMACEUTICALLY ACTIVE QUINAZOLINE COMPOUNDS Astra Pharmaceuticals Limited (GB) 1998-08-19 EP disclosed
WO-1997014686-A1 PHARMACEUTICALLY ACTIVE QUINAZOLINE COMPOUNDS ASTRA PHARMACEUTICALS LIMITED (GB) 1997-04-24 WO disclosed