Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 17/20 | 0.72 |
| ▸ | PDK2 | Q15119 | 17/20 | 0.72 |
| ▸ | PDK3 | Q15120 | 17/20 | 0.72 |
| ▸ | PDK4 | Q16654 | 17/20 | 0.72 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.67 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.61 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6349034 | 0.94 | PDK1 (0.81) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL3784169 | 0.94 | PDK1 (0.81) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5737699 | 0.89 | PTGES2 (0.81) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL6348877 | 0.85 | PDK1 (1.00) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL5735974 | 0.85 | PDK1 (1.00) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL4609853 | 0.85 | PDK1 (0.74) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL4609857 | 0.85 | PDK1 (0.74) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL4608406 | 0.85 | PDK1 (0.74) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL6351516 | 0.84 | PDK1 (1.00) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL6351437 | 0.84 | PDK1 (1.00) | PDK1PDK2PDK3PDK4PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064274-A1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | AstraZeneca AB (SE) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999047508-A1 | BENZENESULFONAMIDE-DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 1999-09-23 | — | — | WO | disclosed |