Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.38 |
| ▸ | HRAS | P01112 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7800926 | 0.88 | HRAS (0.40) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL7118414 | 0.86 | HRAS (0.48) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL7117804 | 0.86 | HRAS (0.48) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL8444844 | 0.85 | GRM1 (0.32) | — | |
| SCHEMBL8442943 | 0.85 | GRM1 (0.32) | — | |
| SCHEMBL7647214 | 0.84 | HRAS (0.45) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL7803321 | 0.82 | TOP1 (0.43) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL7645811 | 0.80 | TOP1 (0.37) | TOP1HRASESR1ESR2KDM4E | |
| SCHEMBL7813677 | 0.78 | ITGB3 (0.35) | KDM4EMAPTHDAC1 | |
| SCHEMBL6781964 | 0.78 | HRAS (0.43) | TOP1HRASESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915845-B1 | ACRYLOYL SUBSTITUTED DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA & UPJOHN SPA (IT) | 2001-09-12 | — | — | EP | disclosed |