Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 8/20 | 0.69 |
| ▸ | TDO2 | P48775 | 5/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | PTPRC | P08575 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | USP19 | O94966 | 1/20 | 0.37 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7808047 | 0.83 | IDO1 (0.79) | IDO1TDO2PTGS2USP1USP19 | |
| SCHEMBL7816954 | 0.82 | IDO1 (1.00) | IDO1TDO2PTGS2NPC1ALDH1A1 | |
| SCHEMBL7805767 | 0.78 | IDO1 (0.71) | IDO1TDO2PTGS2MAOBUSP1 | |
| Sulfuric Acid SCHEMBL7813028 | 0.77 | IDO1 (0.89) | IDO1TDO2PTGS2NPC1ALDH1A1 | |
| SCHEMBL7805851 | 0.75 | IDO1 (0.63) | IDO1TDO2USP1USP19WDR48 | |
| SCHEMBL7812685 | 0.75 | IDO1 (0.72) | IDO1TDO2PTGS2USP1NPC1 | |
| SCHEMBL7805902 | 0.75 | IDO1 (0.63) | IDO1TDO2PTGS2PTPRCNPC1 | |
| SCHEMBL7811800 | 0.75 | IDO1 (0.62) | IDO1TDO2PTGS2NPC1ALDH1A1 | |
| SCHEMBL7805716 | 0.74 | IDO1 (0.62) | IDO1TDO2PTGS2MAOBSMN1; SMN2 | |
| SCHEMBL7815259 | 0.73 | IDO1 (0.63) | IDO1TDO2PTPRCALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | claimed |
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |