Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 7/20 | 0.63 |
| ▸ | TDO2 | P48775 | 5/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815304 | 0.88 | IDO1 (0.55) | IDO1TDO2PTGS2MAPTALDH1A1 | |
| SCHEMBL7805767 | 0.83 | IDO1 (0.71) | IDO1TDO2PTGS2MAPTALDH1A1 | |
| SCHEMBL7808047 | 0.81 | IDO1 (0.79) | IDO1TDO2PTGS2MEN1KMT2A | |
| SCHEMBL7805716 | 0.79 | IDO1 (0.62) | IDO1TDO2PTGS2SMN1; SMN2DHODH | |
| SCHEMBL6008193 | 0.79 | PTGS2 (0.44) | IDO1TDO2PTGS2ALDH1A1KDM4E | |
| SCHEMBL7816954 | 0.78 | IDO1 (1.00) | IDO1TDO2PTGS2MAPTALDH1A1 | |
| SCHEMBL7974992 | 0.76 | IDO1 (1.00) | IDO1TDO2MAPTKMT2AALDH1A1 | |
| SCHEMBL7811800 | 0.76 | IDO1 (0.62) | IDO1TDO2PTGS2MAPTMEN1 | |
| SCHEMBL7816639 | 0.75 | IDO1 (0.57) | IDO1TDO2MAPTMEN1KMT2A | |
| SCHEMBL7815259 | 0.75 | IDO1 (0.63) | IDO1TDO2ALDH1A1RAB9APTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | claimed |
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |