Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 7/20 | 0.53 |
| ▸ | TDO2 | P48775 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.32 |
| ▸ | USP19 | O94966 | 1/20 | 0.32 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | USP8 | P40818 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807731 | 0.80 | IDO1 (0.52) | IDO1TDO2RAB9AALDH1A1MAPT | |
| SCHEMBL7813124 | 0.80 | IDO1 (0.55) | IDO1TDO2RAB9AALDH1A1MAPT | |
| SCHEMBL7816639 | 0.79 | IDO1 (0.57) | IDO1TDO2ALDH1A1MAPTMAOB | |
| SCHEMBL7811786 | 0.76 | IDO1 (0.53) | IDO1TDO2RAB9AALDH1A1MAPT | |
| SCHEMBL7811377 | 0.75 | IDO1 (0.52) | IDO1TDO2RAB9AALDH1A1MAPT | |
| SCHEMBL7814769 | 0.74 | IDO1 (0.55) | IDO1TDO2RAB9AALDH1A1MAPT | |
| SCHEMBL7808342 | 0.74 | IDO1 (0.55) | IDO1TDO2RAB9AALDH1A1MAPT | |
| SCHEMBL7811891 | 0.74 | IDO1 (0.55) | IDO1TDO2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7808047 | 0.73 | IDO1 (0.79) | IDO1TDO2ALDH1A1USP1USP19 | |
| SCHEMBL7805851 | 0.72 | IDO1 (0.63) | IDO1TDO2RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | claimed |
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |
| EP-0876356-A1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | LABORATOIRE INNOTHERA Société Anonyme (FR) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997021684-A1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | LABORATOIRE INNOTHERA, SOCIETE ANONYME (FR) | 1997-06-19 | — | — | WO | disclosed |