Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 8/20 | 0.55 |
| ▸ | TDO2 | P48775 | 5/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | USP1 | O94782 | 2/20 | 0.35 |
| ▸ | USP19 | O94966 | 2/20 | 0.35 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.33 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.33 |
| ▸ | CTRC | Q99895 | 1/20 | 0.33 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7813124 | 0.83 | IDO1 (0.55) | IDO1TDO2USP1USP19WDR48 | |
| SCHEMBL7811891 | 0.83 | IDO1 (0.55) | IDO1TDO2ADORA2AADORA1USP1 | |
| SCHEMBL7814769 | 0.83 | IDO1 (0.55) | IDO1TDO2ADORA2AADORA1USP1 | |
| SCHEMBL7812948 | 0.81 | IDO1 (0.52) | IDO1TDO2NPC1ALDH1A1MAPT | |
| SCHEMBL7811413 | 0.79 | IDO1 (0.50) | IDO1TDO2NPC1RAB9A | |
| SCHEMBL7816639 | 0.77 | IDO1 (0.57) | IDO1TDO2ADORA2AADORA1ALDH1A1 | |
| SCHEMBL7805846 | 0.77 | IDO1 (0.48) | IDO1TDO2NPC1ALDH1A1MAPT | |
| SCHEMBL7818266 | 0.77 | IDO1 (0.55) | IDO1TDO2USP1USP19WDR48 | |
| SCHEMBL7807731 | 0.76 | IDO1 (0.52) | IDO1TDO2USP1USP19WDR48 | |
| SCHEMBL7811377 | 0.76 | IDO1 (0.52) | IDO1TDO2USP1USP19WDR48 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | claimed |
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |