Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | AGXT | P21549 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254330 | 0.86 | MEN1 (0.49) | MEN1MAPTKMT2AIDO1CYP1A2 | |
| SCHEMBL7829968 | 0.85 | HSP90AB1 (0.46) | MEN1MAPTKMT2AIDO1HSP90AB1 | |
| SCHEMBL10540278 | 0.85 | ESR1 (0.52) | MEN1MAPTKMT2AIDO1CYP1A2 | |
| SCHEMBL7836753 | 0.80 | HSP90AB1 (0.39) | MAOBMEN1MAPTKMT2AIDO1 | |
| SCHEMBL29074259 | 0.79 | ALDH1A1 (0.50) | MEN1MAPTKMT2AIDO1TP53 | |
| SCHEMBL7840421 | 0.77 | CYP1A2 (0.51) | MEN1MAPTKMT2AIDO1TP53 | |
| SCHEMBL1106684 | 0.76 | IDO1 (0.58) | MEN1MAPTKMT2AIDO1HSP90AB1 | |
| SCHEMBL7806593 | 0.76 | KMT2A (0.36) | MAOBMEN1MAPTKMT2AIDO1 | |
| SCHEMBL11722438 | 0.74 | IDO1 (0.56) | MAOBMEN1MAPTKMT2AIDO1 | |
| SCHEMBL9192605 | 0.73 | KMT2A (0.47) | MEN1MAPTKMT2AIDO1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091941-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2001-04-18 | — | — | EP | disclosed |
| US-6124463-A | TREATMENT OF AFFECTIVE DISORDER, ANXIETY OR DEPRESSION | DUPONT PHARMACEUTICALS (US) | 2000-09-26 | — | — | US | disclosed |
| WO-2000001675-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-01-13 | — | — | WO | disclosed |