SCHEMBL7806689

SCHEMBL7806689

NC1=NC(c2cccs2)Nc2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 11/20 1.00
NOS3 P29474 3/20 0.64
NOS1 P29475 1/20 0.64
KDM4E B2RXH2 6/20 0.48
ALDH1A1 P00352 4/20 0.48
HPGD P15428 3/20 0.48
MAPT P10636 2/20 0.42
LMNA P02545 1/20 0.42
GLA P06280 1/20 0.42
GAA P10253 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
MEN1 O00255 1/20 0.40
ALOX15 P16050 1/20 0.40
ALOX12 P18054 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 1/20 0.38
RAB9A P51151 1/20 0.38
ADORA3 P0DMS8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8379794 0.98 NOS2 (0.97) NOS2NOS3NOS1KDM4EALDH1A1
SCHEMBL7802867 0.79 NOS2 (1.00) NOS2NOS3NOS1KDM4EALDH1A1
SCHEMBL7803363 0.79 NOS2 (0.72) NOS2NOS3NOS1KDM4EALDH1A1
Hydrochloric Acid SCHEMBL8378587 0.77 NOS2 (0.70) NOS2NOS3NOS1KDM4EALDH1A1
Hydrochloric Acid SCHEMBL8379640 0.77 NOS2 (0.97) NOS2NOS3NOS1KDM4EALDH1A1
SCHEMBL7804437 0.76 NOS2 (0.61) NOS2NOS3NOS1KDM4EALDH1A1
SCHEMBL7802794 0.75 NOS2 (1.00) NOS2NOS3NOS1KDM4EALDH1A1
Hydrochloric Acid SCHEMBL8381046 0.75 NOS2 (0.59) NOS2NOS3NOS1KDM4EALDH1A1
SCHEMBL7802808 0.74 NOS2 (0.78) NOS2NOS3NOS1KDM4EALDH1A1
Hydrochloric Acid SCHEMBL8378309 0.73 NOS2 (0.96) NOS2NOS3NOS1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248745-B1 MIXTURE COMPRISING A CYCLOOXYGENASE-2 (COX-2) INHIBITOR AND A 1,2-DIHYDRO-4-AMINOQUINAZOLINE DERIVATIVE INHIBITOR OF INDUCED NITRIC OXIDE SYNTHASE (INOS); NON-STEROIDAL ANTIINFLAMMATORY AGENTS ASTRAZENECA AB (SE) 2001-06-19 US claimed
EP-1100505-A1 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR AstraZeneca AB (SE) 2001-05-23 EP claimed
WO-2000000200-A1 A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR AND A iNOS INHIBITOR ASTRAZENECA AB (SE) 2000-01-06 WO claimed
CN-1204327-A Pharmaceutically active quinazoline compounds ASTRA PHARMA PROD (GB) 1999-01-06 CN disclosed