Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 8/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.56 |
| ▸ | RHEB | Q15382 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7806906 | 0.88 | GRIN1 (0.62) | GRIN1GRIN2BRHEBRAB9ATDP1 | |
| SCHEMBL7811234 | 0.88 | GRIN1 (0.49) | GRIN1GRIN2BRHEBKMT2ANPC1 | |
| SCHEMBL7807032 | 0.87 | TDP1 (0.43) | GRIN1GRIN2BRHEBKMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL8478920 | 0.86 | GRIN1 (0.47) | GRIN1GRIN2BRHEBKMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL8480108 | 0.86 | TDP1 (0.42) | GRIN1GRIN2BRHEBKMT2ANPC1 | |
| SCHEMBL7807068 | 0.85 | GRIN1 (0.56) | GRIN1GRIN2BKMT2ANPC1TP53 | |
| SCHEMBL7808653 | 0.85 | GRIN1 (0.56) | GRIN1GRIN2BKMT2ANPC1TP53 | |
| SCHEMBL7808790 | 0.85 | GRIN1 (0.56) | GRIN1GRIN2BKMT2ANPC1TP53 | |
| SCHEMBL7806830 | 0.85 | TDP1 (0.49) | GRIN1GRIN2BRHEBNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8474413 | 0.84 | GRIN1 (0.55) | GRIN1GRIN2BKMT2ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820990-B1 | Benzimidazole, benzoxazole, and benzothiazole derivatives useful as interleukin 1beta inhibitors | ADIR (FR) | 2001-01-17 | — | — | EP | disclosed |
| US-5972968-A | INTERLEUKIN INHIBITOR | ADIR ET COMPAGNIE (FR) | 1999-10-26 | — | — | US | disclosed |
| EP-0820990-A2 | Novel benzimidazole, benzoxazole, and benzothiazole derivatives useful as interleukin 1beta inhibitors | ADIR ET COMPAGNIE (FR) | 1998-01-28 | — | — | EP | disclosed |