Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.54 |
| ▸ | HTR1B | P28222 | 10/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8033577 | 0.99 | HTR1D (0.53) | HTR1DHTR1BDRD2DRD4DRD3 | |
| SCHEMBL7804093 | 0.91 | HTR1D (0.54) | HTR1DHTR1BDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8021793 | 0.90 | HTR1D (0.53) | HTR1DHTR1BDRD2DRD4DRD3 | |
| SCHEMBL7804160 | 0.85 | HTR1D (0.56) | HTR1DHTR1BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL8032981 | 0.85 | HTR1D (0.55) | HTR1DHTR1BSIGMAR1 | |
| SCHEMBL7805968 | 0.82 | HTR1D (0.53) | HTR1DHTR1BP2RX7SIGMAR1HTR2A | |
| Hydrochloric Acid SCHEMBL8021891 | 0.81 | HTR1D (0.52) | HTR1DHTR1BP2RX7SIGMAR1HTR2A | |
| SCHEMBL7806971 | 0.79 | DRD3 (0.60) | HTR1DHTR1BDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8031131 | 0.78 | DRD3 (0.59) | HTR1DHTR1BDRD2DRD4DRD3 | |
| SCHEMBL7805932 | 0.78 | HTR1D (0.54) | HTR1DHTR1BSIGMAR1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |