Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.60 |
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | DRD4 | P21917 | 3/20 | 0.60 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8031131 | 0.99 | DRD3 (0.59) | DRD3DRD2DRD4HTR1DHTR1B | |
| SCHEMBL7804093 | 0.88 | HTR1D (0.54) | DRD3DRD2DRD4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL8021793 | 0.87 | HTR1D (0.53) | DRD3DRD2DRD4HTR1DHTR1B | |
| SCHEMBL7804144 | 0.86 | KCNH2 (0.50) | DRD3DRD2DRD4HTR1DHTR1B | |
| SCHEMBL7805927 | 0.86 | HTR7 (0.50) | DRD3DRD2DRD4HTR1DHTR1B | |
| SCHEMBL7808859 | 0.86 | DRD2 (0.51) | DRD3DRD2HTR1AHTR7SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8031163 | 0.86 | KCNH2 (0.49) | DRD3DRD2DRD4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL8035305 | 0.85 | DRD2 (0.50) | DRD3DRD2HTR1AHTR7SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8021825 | 0.85 | HTR7 (0.49) | DRD3DRD2DRD4HTR1DHTR1B | |
| SCHEMBL7805912 | 0.83 | HTR1D (0.51) | DRD3DRD2DRD4HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |