Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | PRKACA | P17612 | 5/20 | 0.44 |
| ▸ | MYLK | Q15746 | 4/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.44 |
| ▸ | PRKACG | P22612 | 4/20 | 0.44 |
| ▸ | PRKACB | P22694 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.44 |
| ▸ | PRKX | P51817 | 3/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811383 | 0.90 | ROCK2 (0.45) | ROCK2ROCK1CYP3A4PRKACAMYLK | |
| SCHEMBL7808941 | 0.88 | ROCK2 (0.45) | ROCK2ROCK1CYP3A4PRKACAMYLK | |
| SCHEMBL7811525 | 0.87 | ROCK2 (0.48) | ROCK2ROCK1CYP3A4PRKACAMYLK | |
| SCHEMBL7802285 | 0.86 | ROCK2 (0.48) | ROCK2ROCK1CYP3A4PRKACAMYLK | |
| SCHEMBL7807444 | 0.86 | ROCK2 (0.48) | ROCK2ROCK1CYP3A4PRKACAMYLK | |
| SCHEMBL7811484 | 0.86 | ROCK2 (0.48) | ROCK2ROCK1CYP3A4PRKACAMYLK | |
| SCHEMBL7811468 | 0.86 | ROCK2 (0.48) | ROCK2ROCK1CYP3A4PRKACAMYLK | |
| SCHEMBL7802435 | 0.86 | ROCK2 (0.48) | ROCK2ROCK1CYP3A4PRKACAMYLK | |
| SCHEMBL7802358 | 0.86 | ROCK2 (0.49) | ROCK2ROCK1CYP3A4PRKACAMYLK | |
| SCHEMBL7807330 | 0.86 | ROCK2 (0.44) | ROCK2ROCK1CYP3A4PRKACAMYLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074545-A1 | ISOQUINOLINESULFONAMIDE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Hidaka, Hiroyoshi (JP) | 2001-02-07 | — | — | EP | disclosed |