Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3570959 | 0.82 | ALOX5 (0.47) | ALOX5PIK3CDKMT2A | |
| SCHEMBL3571404 | 0.82 | ALOX5 (0.43) | ALOX5PIK3CDKMT2A | |
| SCHEMBL8173632 | 0.81 | ALOX5 (0.67) | ALOX5KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL7811821 | 0.81 | ALOX5 (0.42) | ALOX5PIK3CDKMT2A | |
| SCHEMBL3568520 | 0.80 | ALOX5 (0.43) | ALOX5PIK3CDKMT2A | |
| SCHEMBL3568405 | 0.80 | ALOX5 (0.43) | ALOX5PIK3CDKMT2A | |
| SCHEMBL6571511 | 0.80 | ALOX5 (0.68) | ALOX5PIK3CDALDH1A1KMT2A | |
| SCHEMBL3574601 | 0.80 | ALOX5 (0.42) | ALOX5PIK3CDKMT2A | |
| SCHEMBL3575020 | 0.80 | ALOX5 (0.43) | ALOX5PIK3CDNPSR1 | |
| SCHEMBL3565479 | 0.79 | ALOX5 (0.42) | ALOX5PIK3CDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787127-B1 | 5-LIPOXYGENASE INHIBITORS | PFIZER (US) | 2001-01-03 | — | — | EP | disclosed |
| US-6063928-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, CARDIOTONIC AGENTS | PFIZER INC (US) | 2000-05-16 | — | — | US | disclosed |
| US-5883106-A | 5-lipoxygenase inhibitors | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0787127-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996011911-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | disclosed |