Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31270697 | 0.91 | LMNA (0.74) | LMNAL3MBTL1KCNH2ALDH1A1POLB | |
| SCHEMBL169675 | 0.85 | LMNA (0.68) | LMNAL3MBTL1KCNH2ALDH1A1POLB | |
| SCHEMBL31729500 | 0.85 | LMNA (0.68) | LMNAL3MBTL1KCNH2ALDH1A1POLB | |
| SCHEMBL2950629 | 0.84 | LMNA (0.71) | LMNAL3MBTL1KCNH2ALDH1A1POLB | |
| SCHEMBL301107 | 0.84 | LMNA (0.66) | LMNAL3MBTL1KCNH2ALDH1A1POLB | |
| Iodomethane SCHEMBL11514034 | 0.82 | LMNA (0.59) | LMNAL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL277927 | 0.82 | LMNA (0.64) | LMNAL3MBTL1KCNH2ALDH1A1POLB | |
| SCHEMBL17102309 | 0.82 | LMNA (0.64) | LMNAL3MBTL1KCNH2ALDH1A1POLB | |
| SCHEMBL11113913 | 0.82 | LMNA (0.64) | LMNAL3MBTL1KCNH2ALDH1A1POLB | |
| SCHEMBL26789087 | 0.82 | LMNA (0.64) | LMNAL3MBTL1KCNH2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1093536-C | 5-lipoxygenase inhibitors | PFIZER (US) | 2002-10-30 | — | — | CN | disclosed |
| EP-0787127-B1 | 5-LIPOXYGENASE INHIBITORS | PFIZER (US) | 2001-01-03 | — | — | EP | disclosed |
| US-6063928-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, CARDIOTONIC AGENTS | PFIZER INC (US) | 2000-05-16 | — | — | US | disclosed |
| US-5883106-A | 5-lipoxygenase inhibitors | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |
| CN-1169722-A | 5-lipoxygenase inhibitors | PFIZER (US) | 1998-01-07 | — | — | CN | disclosed |
| EP-0787127-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996011911-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | disclosed |