Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.42 |
| ▸ | CTSG | P08311 | 3/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.42 |
| ▸ | CMA1 | P23946 | 3/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8511586 | 0.76 | POLB (0.51) | POLBSRCPRSS1CTSGCTRB1 | |
| SCHEMBL8511582 | 0.76 | POLB (0.51) | POLBSRCPRSS1CTSGCTRB1 | |
| SCHEMBL8511583 | 0.76 | POLB (0.51) | POLBSRCPRSS1CTSGCTRB1 | |
| SCHEMBL10438916 | 0.72 | POLB (0.50) | POLBSRCPRSS1CTSGCTRB1 | |
| SCHEMBL10788978 | 0.71 | POLB (0.53) | POLBSRCPRSS1CTSGCTRB1 | |
| SCHEMBL31385570 | 0.71 | PRSS1 (0.55) | SRCPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL28569677 | 0.71 | KCNN4 (0.43) | SRCCTRB1ELANEPTGS1PTGS2 | |
| SCHEMBL28676616 | 0.71 | KMT2A (0.43) | SRCPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL24571837 | 0.71 | POLB (0.56) | POLBPRSS1CTSGCTRB1CMA1 | |
| SCHEMBL13994623 | 0.71 | POLB (0.56) | POLBPRSS1CTSGCTRB1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010148488-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES | MERCK FROSST CANADA LTD. (CA) | 2010-12-29 | — | — | WO | disclosed |