Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.89 |
| ▸ | TP53 | P04637 | 2/20 | 0.89 |
| ▸ | RAB9A | P51151 | 2/20 | 0.89 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.66 |
| ▸ | CHKA | P35790 | 4/20 | 0.66 |
| ▸ | MC4R | P32245 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811609 | 0.92 | NPC1 (0.78) | NPC1TP53RAB9AKDM4EMEN1 | |
| SCHEMBL31484892 | 0.90 | HRH3 (0.78) | NPC1TP53RAB9AKDM4EMEN1 | |
| SCHEMBL7809854 | 0.88 | NPC1 (0.73) | NPC1TP53RAB9AKDM4EMEN1 | |
| SCHEMBL7809622 | 0.88 | NPC1 (0.92) | NPC1TP53RAB9AKDM4EMEN1 | |
| SCHEMBL1143656 | 0.87 | NPC1 (0.85) | NPC1TP53RAB9AKDM4EMEN1 | |
| SCHEMBL7807819 | 0.86 | HRH3 (0.82) | NPC1TP53RAB9AKDM4EMEN1 | |
| SCHEMBL7809890 | 0.86 | NPC1 (0.70) | NPC1TP53RAB9AKDM4EMEN1 | |
| SCHEMBL2321293 | 0.85 | MC4R (0.85) | NPC1TP53RAB9AKDM4EALDH1A1 | |
| SCHEMBL16356430 | 0.85 | MC4R (0.85) | NPC1TP53RAB9AKDM4EALDH1A1 | |
| SCHEMBL8916186 | 0.85 | MC4R (0.85) | NPC1TP53RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140880-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | claimed |
| WO-2000039110-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | claimed |
| EP-1140880-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039110-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |