SCHEMBL7811609

SCHEMBL7811609

c1ccc(COc2ccc(CN3CCCN(Cc4ccccc4)CC3)cc2)cc1

nearest known ligand 0.78

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.78
RAB9A P51151 3/20 0.78
TP53 P04637 2/20 0.78
KDM4E B2RXH2 1/20 0.78
MEN1 O00255 1/20 0.78
ALDH1A1 P00352 1/20 0.78
KMT2A Q03164 1/20 0.78
SMN1; SMN2 Q16637 1/20 0.78
NPSR1 Q6W5P4 1/20 0.78
HRH3 Q9Y5N1 11/20 0.76
MAPT P10636 1/20 0.67
HTT P42858 1/20 0.67
LTA4H P09960 1/20 0.63
FAAH O00519 1/20 0.62
SIGMAR1 Q99720 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31484892 0.98 HRH3 (0.78) NPC1RAB9ATP53KDM4EMEN1
SCHEMBL1143656 0.95 NPC1 (0.85) NPC1RAB9ATP53KDM4EMEN1
SCHEMBL3039278 0.93 HRH3 (0.71) NPC1RAB9ATP53KDM4EMEN1
SCHEMBL7809622 0.93 NPC1 (0.92) NPC1RAB9ATP53KDM4EMEN1
SCHEMBL7807819 0.92 HRH3 (0.82) NPC1RAB9ATP53KDM4EMEN1
SCHEMBL7808307 0.92 NPC1 (0.89) NPC1RAB9ATP53KDM4EMEN1
SCHEMBL7809854 0.90 NPC1 (0.73) NPC1RAB9ATP53KDM4EMEN1
SCHEMBL3040585 0.89 HRH3 (0.74) NPC1RAB9ATP53KDM4EMEN1
SCHEMBL7808400 0.89 NPC1 (0.64) NPC1RAB9ATP53KDM4EMEN1
SCHEMBL7815776 0.89 NPC1 (0.67) NPC1RAB9ATP53KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140880-A1 HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS AstraZeneca AB (SE) 2001-10-10 EP claimed
WO-2000039110-A1 HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS ASTRAZENECA AB (SE) 2000-07-06 WO claimed
EP-1140880-A1 HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS AstraZeneca AB (SE) 2001-10-10 EP disclosed
WO-2000039110-A1 HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS ASTRAZENECA AB (SE) 2000-07-06 WO disclosed