SCHEMBL7808372

SCHEMBL7808372

Cc1ccc2c(-c3ccoc3)cc(=O)oc2c1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA12 O43570 7/20 0.56
CA9 Q16790 7/20 0.56
ALOX5 P09917 2/20 0.47
ALDH1A1 P00352 4/20 0.47
KCNA3 P22001 1/20 0.46
ALDH2 P05091 1/20 0.44
AKR1B1 P15121 1/20 0.44
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
HSD17B3 P37058 1/20 0.44
SORD Q00796 1/20 0.44
NOD2 Q9HC29 1/20 0.43
HPGD P15428 2/20 0.42
NPC1 O15118 2/20 0.41
GAA P10253 2/20 0.41
USP2 O75604 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9261782 0.82 CA12 (0.67) CA12CA9ALOX5ALDH1A1ALDH2
SCHEMBL7808379 0.82 ALOX5 (0.47) CA12CA9ALOX5ALDH1A1ALDH2
SCHEMBL7812979 0.82 ALOX5 (0.47) CA12CA9ALOX5ALDH1A1ALDH2
SCHEMBL14424517 0.82 CA12 (0.61) CA12CA9ALDH1A1ALDH2AKR1B1
SCHEMBL12226980 0.80 CA9 (0.68) CA12CA9ALDH1A1KCNA3ALDH2
SCHEMBL7803960 0.79 ALOX5 (0.51) CA12CA9ALOX5ALDH1A1ALDH2
SCHEMBL18788580 0.78 KCNA3 (0.67) ALDH1A1KCNA3ALDH2HPGDSMN1; SMN2
SCHEMBL4077549 0.78 CA12 (0.65) CA12CA9ALOX5ALDH1A1ALDH2
SCHEMBL7816278 0.76 ALOX5 (0.50) CA12CA9ALOX5ALDH1A1ALDH2
SCHEMBL759601 0.74 CA12 (0.64) CA12CA9ALDH1A1KCNA3ALDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0788497-B1 BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC (CA) 2001-05-23 EP disclosed
EP-0788490-B1 BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC (CA) 2000-07-05 EP disclosed
EP-0788490-A1 BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1997-08-13 EP disclosed
EP-0788497-A1 BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1997-08-13 EP disclosed
US-5576338-A ANTIALLERGENS, ANTIHISTAMINES, ANTIINFLAMMATORY AGENTS AND CYTOPROTECTIVE AGENTS FOR CARDIOVASCULAR DISORDERS MERCK FROSST CANADA, INC. (CA) 1996-11-19 US disclosed
US-5552437-A ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY, AND CYTOPROTECTIVE AGENTS MERCK FROSST CANADA, INC. (CA) 1996-09-03 US disclosed
US-5527827-A ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY AND CYTOPROTECTIVE AGENTS MERCK FROSST CANADA, INC. (CA) 1996-06-18 US disclosed
WO-1996013491-A1 BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1996-05-09 WO disclosed
WO-1996013500-A1 BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1996-05-09 WO disclosed
US-5424320-A Antihistamine, antiallergic, antiinflammatory and cytoprotective agents MERCK FROSST CANADA, INC. (CA) 1995-06-13 US disclosed
US-5360815-A Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthesis MERCK FROSST CANADA, INC. (CA) 1994-11-01 US disclosed