Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810676 | 0.91 | HDAC8 (0.55) | MAPK1CYP3A4SLC6A2SLC6A4ADRA1A | |
| SCHEMBL7604289 | 0.83 | SLC6A2 (0.55) | MAPK1CYP3A4SLC6A2SLC6A4ADRA1A | |
| SCHEMBL9590321 | 0.78 | TSHR (0.59) | ADRA1AHTTKMT2ANPSR1KDM4E | |
| SCHEMBL2296426 | 0.77 | KDM4E (0.61) | ADRA1AHTTKMT2ANPSR1KDM4E | |
| SCHEMBL7808599 | 0.76 | SLC6A4 (0.54) | MAPK1CYP3A4SLC6A2SLC6A4ADRA1A | |
| SCHEMBL7813757 | 0.76 | SLC6A4 (0.54) | MAPK1CYP3A4SLC6A2SLC6A4ADRA1A | |
| SCHEMBL7634140 | 0.76 | TSHR (0.56) | MAPK1CYP3A4ADRA1AHTTKMT2A | |
| SCHEMBL7609172 | 0.75 | HDAC8 (0.61) | MAPK1CYP3A4SLC6A2SLC6A4ADRA1A | |
| Hydrochloric Acid SCHEMBL7813755 | 0.75 | CYP3A4 (0.55) | MAPK1CYP3A4SLC6A2SLC6A4ADRA1A | |
| SCHEMBL11159593 | 0.75 | TSHR (0.62) | ADRA1AHTTKMT2ANPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820443-B1 | HETEROCYCLIC COMPOUNDS FOR TREATING DIABETES | NOVO NORDISK AS (DK) | 2001-09-19 | — | — | EP | disclosed |
| EP-0820443-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996031481-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1996-10-10 | — | — | WO | disclosed |