Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8478379 | 0.99 | NPSR1 (0.53) | TDP1NPSR1GAAPKMTSHR | |
| SCHEMBL7808442 | 0.89 | TDP1 (0.42) | TDP1NPSR1GAAPKMTSHR | |
| Hydrochloric Acid SCHEMBL8478371 | 0.88 | NPSR1 (0.44) | TDP1NPSR1GAAPKMTSHR | |
| SCHEMBL7806924 | 0.84 | TDP1 (0.54) | TDP1NPSR1GAAPKMTSHR | |
| Hydrochloric Acid SCHEMBL8480221 | 0.83 | NPSR1 (0.55) | TDP1NPSR1GAAPKMTSHR | |
| SCHEMBL19441071 | 0.78 | TDP1 (0.59) | TDP1NPSR1MAPTKDM4EALDH1A1 | |
| SCHEMBL7806922 | 0.73 | TDP1 (0.43) | TDP1NPSR1GAAPKMTSHR | |
| SCHEMBL21023268 | 0.73 | TDP1 (0.44) | TDP1NPSR1GAAPKMTSHR | |
| SCHEMBL520978 | 0.72 | RAD52 (0.69) | TDP1NPSR1GAAPKMRAB9A | |
| Hydrochloric Acid SCHEMBL8480219 | 0.72 | NPSR1 (0.45) | TDP1NPSR1GAARAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820990-B1 | Benzimidazole, benzoxazole, and benzothiazole derivatives useful as interleukin 1beta inhibitors | ADIR (FR) | 2001-01-17 | — | — | EP | disclosed |
| EP-0820990-A2 | Novel benzimidazole, benzoxazole, and benzothiazole derivatives useful as interleukin 1beta inhibitors | ADIR ET COMPAGNIE (FR) | 1998-01-28 | — | — | EP | disclosed |