Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.51 |
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | INSR | P06213 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7806330 | 0.92 | ALK (0.49) | ALKKDRKITINSRABL1 | |
| SCHEMBL897391 | 0.89 | ALK (0.66) | ALKKDRKITINSRABL1 | |
| SCHEMBL1755990 | 0.89 | ALK (0.55) | ALKKDR | |
| SCHEMBL7820167 | 0.86 | ALK (0.68) | ALKKDRKITINSRABL1 | |
| SCHEMBL897184 | 0.81 | ALK (0.63) | ALKKDRKITINSRABL1 | |
| SCHEMBL7815079 | 0.80 | ALK (0.51) | ALK | |
| SCHEMBL7801032 | 0.79 | ALK (0.57) | ALKKDRINSR | |
| SCHEMBL1755883 | 0.79 | ALK (0.56) | ALK | |
| SCHEMBL7820105 | 0.79 | ALK (0.79) | ALKKDR | |
| SCHEMBL898084 | 0.79 | ALK (0.70) | ALKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |