Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816830 | 0.86 | SIRT2 (0.35) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL7809232 | 0.85 | CYP11B1 (0.33) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL2202154 | 0.80 | CYP11B1 (0.40) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL17651947 | 0.80 | SIRT2 (0.36) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL5688715 | 0.80 | SIRT2 (0.40) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL6965789 | 0.78 | CYP11B1 (0.33) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL7813551 | 0.78 | CYP11B1 (0.33) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL7813567 | 0.78 | SIRT2 (0.36) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL845130 | 0.76 | CYP11B1 (0.43) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL6965487 | 0.75 | SIRT2 (0.33) | SIRT2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889891-B1 | 4-[(THIEN-2-YL)METHYL]IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO MCNEIL PHARM INC (US) | 2001-06-06 | — | — | EP | disclosed |
| EP-0889891-A1 | 4-[(THIEN-2-YL)METHYL]IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO PHARMACEUTICAL CORPORATION (US) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997035857-A1 | 4-[(THIEN-2-YL)METHYL]IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |
| US-5621113-A | ALPHA 2 ADRENOCEPTOR AGONISTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |