Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965789 | 0.85 | CYP11B1 (0.33) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL6969219 | 0.82 | SIRT2 (0.34) | SIRT2IDO1TDO2FLT3TYRO3 | |
| SCHEMBL6971378 | 0.80 | SIRT2 (0.35) | SIRT2CYP11B1CYP11B2FLT3TYRO3 | |
| SCHEMBL7809232 | 0.78 | CYP11B1 (0.33) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL6963184 | 0.75 | CYP11B1 (0.33) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL7809133 | 0.75 | SIRT2 (0.34) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL5060964 | 0.75 | LMNA (0.40) | SIRT2CYP11B1CYP11B2FLT3TYRO3 | |
| SCHEMBL3164127 | 0.75 | SIRT2 (0.37) | SIRT2 | |
| SCHEMBL2202154 | 0.75 | CYP11B1 (0.40) | SIRT2CYP11B1CYP11B2 | |
| SCHEMBL6972517 | 0.74 | SIRT2 (0.34) | SIRT2IDO1TDO2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0954521-B1 | 4- (THIEN-3-YL)METHYL] IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO MCNEIL PHARM INC (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0954521-A1 | 4- (THIEN-3-YL)METHYL] IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | Ortho-McNeil Pharmaceutical, Inc. (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5750720-A | ALPHA-ADRENORECEPTORS AND CENTRAL NERVOUS SYSTEMS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| WO-1997035858-A1 | 4-[(THIEN-3-YL)METHYL] IMIDAZOLE DERIVATIVES HAVING α2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |