SCHEMBL7809147

SCHEMBL7809147

CC1(C)c2cc(OS(=O)(=O)C(F)(F)F)c(Br)cc2C(=O)c2c1[nH]c1cc(N)ccc21

nearest known ligand 0.52

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 20/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1755793 0.89 ALK (0.44) ALK
SCHEMBL7812557 0.88 SRPK1 (0.47) ALK
SCHEMBL897356 0.86 ALK (0.70) ALK
SCHEMBL1755884 0.82 ALK (0.55) ALK
SCHEMBL7811873 0.82 ALK (0.72) ALK
SCHEMBL7806950 0.81 ALK (0.47) ALK
SCHEMBL29940536 0.81 ALK (0.56) ALK
SCHEMBL27087556 0.81 ALK (0.56) ALK
SCHEMBL27087513 0.80 ALK (0.53) ALK
SCHEMBL29940496 0.80 ALK (0.53) ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010143664-A1 TETRACYCLIC COMPOUND 中外製薬株式会社 (JP) 2010-12-16 WO disclosed