Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 9/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 8/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 7/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 7/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 7/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | PDE9A | O76083 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16073068 | 0.75 | ADRA2A (0.60) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL15087184 | 0.74 | ADRA2A (0.64) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL8542548 | 0.73 | ADRA2A (0.57) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL25634740 | 0.72 | GAA (0.80) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL4230288 | 0.72 | GAA (0.64) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL11219654 | 0.72 | GAA (0.64) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL30072908 | 0.71 | GAA (0.57) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL10639862 | 0.70 | GAA (0.72) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL11228831 | 0.70 | GAA (0.62) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL17528585 | 0.70 | ADRA2A (0.53) | ADRA2AADRA2CADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741709-B1 | AROMATIC 2-AMINO-IMIDAZOLE DERIVATIVES AS ALPHA-2A ADRENOCEPTOR AGONISTS | ALLERGAN SALES INC (US) | 2001-07-25 | — | — | EP | claimed |
| EP-0741709-A1 | AROMATIC 2-AMINO-IMIDAZOLE DERIVATIVES AS ALPHA-2A ADRENOCEPTOR AGONISTS | Allergan (US) | 1996-11-13 | — | — | EP | claimed |
| WO-1995019968-A1 | AROMATIC 2-AMINO-IMIDAZOLE DERIVATIVES AS ALPHA-2A ADRENOCEPTOR AGONISTS | ALLERGAN (US) | 1995-07-27 | — | — | WO | claimed |