Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BCL9 | O00512 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | FABP7 | O15540 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7800328 | 0.89 | POLB (0.44) | POLBP2RX4ALDH1A1HPGDGRIN2B | |
| SCHEMBL7800300 | 0.87 | P2RX4 (0.42) | POLBP2RX4ALDH1A1HPGDGRIN2B | |
| SCHEMBL7800279 | 0.85 | BDKRB2 (0.40) | POLBP2RX4ALDH1A1HPGDGRIN2B | |
| SCHEMBL27299245 | 0.85 | POLB (0.54) | POLBALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL8572171 | 0.85 | POLB (0.54) | POLBALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL7806890 | 0.84 | CA12 (0.42) | POLBP2RX4ALDH1A1HPGDGRIN2B | |
| SCHEMBL7806845 | 0.82 | POLB (0.52) | POLBP2RX4ALDH1A1HPGDGRIN2B | |
| SCHEMBL7806843 | 0.82 | POLB (0.52) | POLBP2RX4ALDH1A1HPGDGRIN2B | |
| SCHEMBL7807916 | 0.81 | POLB (0.51) | POLBP2RX4ALDH1A1HPGDGRIN2B | |
| SCHEMBL10390625 | 0.81 | POLB (0.51) | POLBP2RX4ALDH1A1HPGDGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528678-B1 | A pyrrolidylthiocarbapenem derivative with antibacterial activity | SHIONOGI & CO (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5703243-A | Intermediates for pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1997-12-30 | — | — | US | disclosed |
| US-5317016-A | Pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-05-31 | — | — | US | disclosed |
| EP-0528678-A1 | A pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1993-02-24 | — | — | EP | disclosed |