SCHEMBL780921

SCHEMBL780921

c1ccc(-c2cccc(-c3ccc4sc5c(-c6ccc7c(c6)c6cc(-c8cc(-c9cccc(-c%10ccccc%10)c9)cc9c8sc8ccc(-c%10cccc(-c%11ccccc%11)c%10)cc89)ccc6n7-c6ccc(-c7c8ccccc8c(-c8ccccc8)c8ccccc78)cc6)cc(-c6cccc(-c7ccccc7)c6)cc5c4c3)c2)cc1

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LIMK1 P53667 1/20 0.35
ALOX5 P09917 1/20 0.34
PIM3 Q86V86 2/20 0.32
KDM4E B2RXH2 1/20 0.31
ATM Q13315 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
KMT2A Q03164 1/20 0.30
PTPN1 P18031 2/20 0.30
PIM1 P11309 1/20 0.30
PIM2 Q9P1W9 1/20 0.30
TNKS O95271 1/20 0.30
TNKS2 Q9H2K2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL780833 0.98 KDM4E (0.35) LIMK1ALOX5PIM3KDM4EATM
SCHEMBL781080 0.98 LIMK1 (0.36) LIMK1ALOX5PIM3KDM4EATM
SCHEMBL781041 0.98 LIMK1 (0.36) LIMK1ALOX5PIM3KDM4EATM
SCHEMBL781299 0.96 KDM4E (0.36) LIMK1ALOX5PIM3KDM4EATM
SCHEMBL780682 0.96 KDM4E (0.36) LIMK1ALOX5PIM3KDM4EATM
SCHEMBL780865 0.96 LIMK1 (0.35) LIMK1ALOX5PIM3KDM4EATM
SCHEMBL780761 0.94 KDM4E (0.35) LIMK1ALOX5PIM3KDM4EATM
SCHEMBL780740 0.94 LIMK1 (0.35) LIMK1ALOX5PIM3KDM4EATM
SCHEMBL780748 0.93 LIMK1 (0.34) LIMK1ALOX5PIM3
SCHEMBL780658 0.92 KDM4E (0.35) LIMK1ALOX5PIM3KDM4EATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-12-29 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 LIMK1 3472/4885ALOX5 1162/4885PIM3 2594/4885
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 LIMK1 3472/4885ALOX5 1162/4885PIM3 2594/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.